Singlet-oxygen-sensitizing near-infrared-fluorescent multimodal nanoparticles

Edakkattuparambil Sidharth Shibu; Sakiko Sugino; Kenji Ono; Hironobu Saito; Ayama Nishioka; Shohei Yamamura; Makoto Sawada; Yoshio Nosaka; Vasudevanpillai Biju

doi:10.1002/anie.201304264

Singlet-oxygen-sensitizing near-infrared-fluorescent multimodal nanoparticles

Angew Chem Int Ed Engl. 2013 Sep 27;52(40):10559-63. doi: 10.1002/anie.201304264. Epub 2013 Aug 13.

Authors

Edakkattuparambil Sidharth Shibu¹, Sakiko Sugino, Kenji Ono, Hironobu Saito, Ayama Nishioka, Shohei Yamamura, Makoto Sawada, Yoshio Nosaka, Vasudevanpillai Biju

Affiliation

¹ Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa 761-0395 (Japan); PRESTO (Japan) Science and Technology Agency (JST) (Japan).

PMID: 23943605
DOI: 10.1002/anie.201304264

Abstract

Nanoprobes based on quantum clusters (QC) with near-infrared fluorescence, magnetic-resonance-imaging contrast, and singlet-oxygen-sensitized intracellular fluorescence are studied. The generation of singlet oxygen and singlet-oxygen-sensitized fluorescence uncaging by magnetic and NIR-emitting nanoparticles are exploited for multimodal bioimaging in vitro.

Keywords: fluorescence; nanomaterials; photochemistry; quantum clusters; singlet oxygen.

MeSH terms

Fluorescent Dyes / chemistry*
Multimodal Imaging / methods*
Nanoparticles / chemistry*
Photochemical Processes
Singlet Oxygen / chemistry*

Substances

Fluorescent Dyes
Singlet Oxygen