Structurally flexible triethanolamine-core poly(amidoamine) dendrimers as effective nanovectors to deliver RNAi-based therapeutics

Biotechnol Adv. 2014 Jul-Aug;32(4):844-52. doi: 10.1016/j.biotechadv.2013.08.001. Epub 2013 Aug 9.

Abstract

RNAi-based nucleic acid molecules have attracted considerable attention as compelling therapeutics providing safe and competent delivery systems are available. Dendrimers are emerging as appealing nanocarriers for nucleic acid delivery thanks to their unique well-defined architecture and the resulting cooperativity and multivalency confined within a nanostructure. The present review offers a brief overview of the structurally flexible triethanolamine-core poly(amidoamine) (PAMAM) dendrimers developed in our group as nanovectors for the delivery of RNAi therapeutics. Their excellent activity for delivering different RNAi therapeutics in various disease models in vitro and in vivo will be highlighted here.

Keywords: Dendrimer; Gene silencing; Nanovector; RNA interference; RNAi therapeutics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Dendrimers / chemistry*
  • Ethanolamines / chemistry*
  • Humans
  • Mice
  • MicroRNAs / metabolism
  • Nanomedicine / methods*
  • Nanotechnology / methods*
  • Polyamines / chemistry*
  • RNA Interference*
  • RNA, Small Interfering / metabolism

Substances

  • Dendrimers
  • Ethanolamines
  • MicroRNAs
  • PAMAM Starburst
  • Poly(amidoamine)
  • Polyamines
  • RNA, Small Interfering
  • triethanolamine