Acute late-onset encephalopathy after radiotherapy: an unusual life-threatening complication

Anna Luisa Di Stefano; Giulia Berzero; Paolo Vitali; Carlo Andrea Galimberti; Francois Ducray; Mauro Ceroni; Stefano Bastianello; Anna Amelia Colombo; Anna Simoncelli; Marta Claudia Brunelli; Bruno Giometto; Luca Diamanti; Paola Gaviani; Andrea Salmaggi; Antonio Silvani; Enrico Marchioni

doi:10.1212/WNL.0b013e3182a43b1f

Acute late-onset encephalopathy after radiotherapy: an unusual life-threatening complication

Neurology. 2013 Sep 10;81(11):1014-7. doi: 10.1212/WNL.0b013e3182a43b1f. Epub 2013 Aug 9.

Authors

Anna Luisa Di Stefano¹, Giulia Berzero, Paolo Vitali, Carlo Andrea Galimberti, Francois Ducray, Mauro Ceroni, Stefano Bastianello, Anna Amelia Colombo, Anna Simoncelli, Marta Claudia Brunelli, Bruno Giometto, Luca Diamanti, Paola Gaviani, Andrea Salmaggi, Antonio Silvani, Enrico Marchioni

Affiliation

¹ From C. Mondino National Institute of Neurology Foundation (A.L.D., G.B., P.V., C.A.G., M.C., S.B., L.D., E.M.), IRCCS, Pavia, Italy; Neuroscience Consortium (G.B., L.D.), University of Pavia, Monza Policlinico and Pavia Mondino, Italy; Department of Neuro-oncology (F.D.), Hospices Civils de Lyon, Lyon Neuroscience Research Center INSERM U1028/CNRS UMR 5292, Université Claude Bernard Lyon, France; Department of Neuroscience (M.C., S.B.), University of Pavia, Italy; Bone Marrow Transplant Unit (A.A.C.), Department of Hematology Oncology, Foundation IRCCS, Policlinico San Matteo, Pavia, Italy; C.O.U. of Diagnostic Radiology and Interventional Radiology and Neuroradiology (A. Simoncelli), IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; Department of Neurology (M.C.B., B.G.), Ospedale Ca' Foncello, Treviso, Italy; Neuro-oncology Unit (P.G., A. Silvani), Neurological Institute C. Besta, Milan, Italy; and SC Neurologia (A. Salmaggi), Ospedale A. Manzoni, Lecco, Italy.

PMID: 23935180
DOI: 10.1212/WNL.0b013e3182a43b1f

Abstract

Unusual late-onset complications of brain irradiation, characterized by reversible neurologic focal signs, seizures, and MRI alterations, have recently been reported and classified as stroke-like migraine attacks after radiation therapy (SMART)(1) and peri-ictal pseudoprogression (PIPG).(2.)

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Brain Diseases / complications
Brain Diseases / diagnosis
Brain Diseases / etiology*
Electroencephalography
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Radiation Injuries / complications
Radiation Injuries / diagnosis
Radiation Injuries / etiology*
Radiotherapy / adverse effects*
Young Adult