For the first time ever, sorafenib-induced hepatic failure has been cured by liver transplantation. A 54-year-old man, he underwent surgery for papillary carcinoma of thyroid gland two years ago. After two years follow up, a left neck lymph node metastasis was found and he was treated with sorafenib (800 mg/day). However, two days later, hepatic failure associated with sorafenib developed and he was treated with liver transplantation. The donor was a victim of road accident. Even though hepatic failure associated with sorafenib treatment is rare, the possible development of hepatic failure in patients undergoing sorafenib treatment must be kept in mind.