Abstract
The antiviral activity of certain acyclic nucleosides drew our attention to the fact that the replacement of the furanose ring by an alkyl group bearing hydroxyl(s) could be a useful structural modification to modulate the biological properties of those nucleosides. Herein, we report on the synthesis of some novel acadesine analogues, where the ribose moiety is mimicked by a D-ribityl or by a hydroxybutyl chain.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aminoimidazole Carboxamide / analogs & derivatives*
-
Aminoimidazole Carboxamide / chemical synthesis
-
Aminoimidazole Carboxamide / pharmacology
-
Antiviral Agents / chemical synthesis*
-
Antiviral Agents / pharmacology
-
Humans
-
Nucleotides / chemistry
-
Ribonucleosides / chemical synthesis*
-
Ribonucleosides / pharmacology
-
Ribose / chemistry*
-
Structure-Activity Relationship*
-
Viruses / drug effects
Substances
-
Antiviral Agents
-
Nucleotides
-
Ribonucleosides
-
Aminoimidazole Carboxamide
-
acadesine
-
Ribose