Synthesis of highly substituted 4H-pyrido[1,2-a]pyrimidines via a one-pot three-component condensation reaction

Kai Yang; Jinbao Xiang; Guochen Bao; Qun Dang; Xu Bai

doi:10.1021/co400086u

Synthesis of highly substituted 4H-pyrido[1,2-a]pyrimidines via a one-pot three-component condensation reaction

ACS Comb Sci. 2013 Sep 9;15(9):519-24. doi: 10.1021/co400086u. Epub 2013 Aug 22.

Authors

Kai Yang¹, Jinbao Xiang, Guochen Bao, Qun Dang, Xu Bai

Affiliation

¹ The Center for Combinatorial Chemistry and Drug Discovery, The School of Pharmaceutical Sciences and The College of Chemistry, Jilin University , 1266 Fujin Road, Changchun, Jilin 130021, P. R. China.

PMID: 23914724
DOI: 10.1021/co400086u

Abstract

A one-pot three-component reaction, involving condensation of 2-aminopyridines, aldehydes, and ketones/aldehydes under trifluoromethanesulfonic acid catalysis, provides rapid access to highly substituted novel 4H-pyrido[1,2-a]pyrimidines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / chemistry*
Aminopyridines / chemistry*
Catalysis
Ketones / chemistry*
Mesylates / chemistry
Models, Molecular
Molecular Structure
Pyrimidines / chemical synthesis*
Pyrimidines / chemistry

Substances

Aldehydes
Aminopyridines
Ketones
Mesylates
Pyrimidines
trifluoromethanesulfonic acid
alpha-aminopyridine