Abstract
Metastasis is the most significant cause of cancer-associated morbidity and mortality but remains poorly understood. Recent work revealed that metastasis of aggressive triple-negative breast cancers is suppressed by Sharp1, a factor that promotes degradation of hypoxia-inducible factors (HIF) and blunts HIF-induced malignant cell behavior.
MeSH terms
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Animals
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Basic Helix-Loop-Helix Transcription Factors / genetics*
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Basic Helix-Loop-Helix Transcription Factors / metabolism
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Breast Neoplasms / genetics*
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology
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Female
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Humans
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Hypoxia-Inducible Factor 1 / genetics*
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Membrane Proteins / genetics*
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Membrane Proteins / metabolism
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Neoplasm Metastasis
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Triple Negative Breast Neoplasms / genetics*
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Triple Negative Breast Neoplasms / metabolism
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Triple Negative Breast Neoplasms / pathology
Substances
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BHLHE41 protein, human
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Basic Helix-Loop-Helix Transcription Factors
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CKAP4 protein, human
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Hypoxia-Inducible Factor 1
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Membrane Proteins