Arterial infusion therapy was applied to 92 patients with 40 unresectable, 30 non-curatively resected and 22 recurrent gastric cancers. 5-Fluorouracil (5-FU) was administered by arterial continuous infusion, Adriamycin (ADM) and mitomycin C (MMC) were given by bolus infusion in the hospital, and continuous arterial 5-FU infusion and ADM low-dose intermittent bolus infusion chemotherapy (AF therapy) were used for outpatients at home. The clinical effectiveness was evaluated. One-year cumulative survival rate of primary case by Kaplan-Meier method was 21.6%, and that of recurrent gastric cancer was 4.5%. In primary cases, the arterial infusion therapy was more effective in non-curatively resected cases than in unresectable ones. Total periods of infusion for outpatients were longer in efficacious cases. A long-surviving autopsy case was reported. AF therapy was considered an effective supportive treatment without any serious side effects for unresectable, non-curatively resected and recurrent gastric cancer, especially responders.