Cisplatin chemotherapy induces odor perception changes in bronchial cancer patients

P Joussain; A Giboreau; M Fontas; M Laville; T Hummel; P J Souquet; M Bensafi

doi:10.1016/j.lungcan.2013.06.009

Cisplatin chemotherapy induces odor perception changes in bronchial cancer patients

Lung Cancer. 2013 Oct;82(1):168-70. doi: 10.1016/j.lungcan.2013.06.009. Epub 2013 Jul 26.

Authors

P Joussain¹, A Giboreau, M Fontas, M Laville, T Hummel, P J Souquet, M Bensafi

Affiliation

¹ CNRS, UMR5292, INSERM U1028, Lyon Neuroscience Research Center, University Lyon, F-69000, France. Electronic address: uline.joussain@olfac.univ-lyon1.fr.

PMID: 23896024
DOI: 10.1016/j.lungcan.2013.06.009

Abstract

A study of olfactory function was performed in 15 bronchial cancer patients receiving cisplatin and 15 control subjects. Whereas odor detection and odor identification abilities were not influenced by the administration of cisplatin, a decrease in pleasantness was observed only for food odors, and not for non-food odors. Taken as a whole, these findings suggest that cisplatin therapy in bronchial cancer patients impairs the pleasure of perceived food odors, which may account for disturbances in food intake and quality of life in this population.

Keywords: Bronchial cancer; Chemotherapy; Cisplatin; Food; Olfaction; pleasantness.

MeSH terms

Aged
Antineoplastic Agents / adverse effects*
Antineoplastic Agents / therapeutic use
Bronchial Neoplasms / drug therapy*
Case-Control Studies
Cisplatin / adverse effects*
Cisplatin / therapeutic use
Food
Humans
Male
Middle Aged
Odorants
Olfaction Disorders / chemically induced*
Quality of Life
Smell / drug effects*

Substances

Antineoplastic Agents
Cisplatin