Tumor-infiltrating regulatory T cells (Tregs) promote immune evasion and are associated with poor disease outcome in patients affected by various malignancies. We have recently demonstrated that several, inherited single nucleotide polymorphisms affecting Treg-related genes influence the survival of ovarian cancer patients, providing novel insights into possible mechanisms of immune escape.
Keywords: CD134; CD80; GARP; GITR; LRRC32; OX40; RGS1; TNFRSF18; TNFRSF4; inherited variants; ovarian cancer; regulatory T cells.