Abstract
Masking the miRNA binding site: Crosslink-forming oligonucleotide (CFO) was used for target gene-specific inhibition of microRNA (miRNA) functions. This method can interfere with specific miRNA-mRNA interactions by recognizing sequences unique to the 3'-UTR that are inherent in each mRNA.
Keywords:
crosslinks; gene expression; mRNA; miRNA; oligonucleotides.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Base Sequence
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Binding Sites / drug effects
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Cross-Linking Reagents / chemistry
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Cross-Linking Reagents / pharmacology*
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Fireflies
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Gene Silencing / drug effects*
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HeLa Cells
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Humans
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Luciferases / chemistry
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Luciferases / genetics
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MicroRNAs*
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Molecular Sequence Data
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Oligodeoxyribonucleotides / chemistry
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Oligodeoxyribonucleotides / pharmacology*
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Purines*
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RNA, Messenger / chemistry*
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RNA, Messenger / metabolism
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Vinyl Compounds*
Substances
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2-amino-6-vinylpurine
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Cross-Linking Reagents
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MicroRNAs
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Oligodeoxyribonucleotides
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Purines
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RNA, Messenger
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Vinyl Compounds
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Luciferases