Abstract
New derivatives of uridine which contain a b-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1-4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were not active against Candida albicans and Aspergilus fumigatus up to the maximum tested concentration of 1,000 µg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / chemical synthesis
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Antifungal Agents / pharmacology
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Aspergillus fumigatus / drug effects
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Candida albicans / drug effects
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Cattle
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology
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Glycosyltransferases / antagonists & inhibitors*
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Glycosyltransferases / metabolism
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Milk / drug effects
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Milk / enzymology
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Structure-Activity Relationship
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Uridine / analogs & derivatives
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Uridine / chemical synthesis*
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Uridine / pharmacology*
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Enzyme Inhibitors
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Glycosyltransferases
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Uridine