Stabilization of α-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition

Boram Kim; Sung-ju Choi; So-hee Han; Kang-Yell Choi; Yong-beom Lim

doi:10.1039/c3cc44644a

Stabilization of α-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition

Chem Commun (Camb). 2013 Sep 7;49(69):7617-9. doi: 10.1039/c3cc44644a. Epub 2013 Jul 19.

Authors

Boram Kim¹, Sung-ju Choi, So-hee Han, Kang-Yell Choi, Yong-beom Lim

Affiliation

¹ Translational Research Center for Protein Function Control, Yonsei University, Seoul 120-749, Korea.

PMID: 23873019
DOI: 10.1039/c3cc44644a

Abstract

A novel strategy to stabilize the α-helical secondary structures of peptides upon binding to gold nanoparticles is described. Using a model protein-protein interaction system, we showed that AuNPs decorated with stabilized p53 α-helix peptides can mediate specific molecular recognition with their target protein.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Circular Dichroism
Gold / chemistry*
Metal Nanoparticles / chemistry*
Peptides / chemistry*
Peptides / metabolism
Protein Structure, Secondary
Surface Properties
Tumor Suppressor Protein p53 / chemistry

Substances

Peptides
Tumor Suppressor Protein p53
Gold