A Raman remote spectroscopy system was established by using flexible hollow fibers (HFs) as laser excitation fiber and signal collection fiber. Experimental evaluations with various optical fiber combinations were carried out. Experiments were conducted by using silver-coated HFs as both remote transmission fiber and sample cells for liquid sample detection. Good linearity for concentration detection of liquid was obtained with clean background and signal enhancement. Theoretical analysis was carried out to optimize the length of the liquid cell. Measured data show good agreement with the simulation result. HF has shown potentiality in applications for remote and noninvasive Raman detection.