Xanthine oxidase inhibition for hyperuricemic heart failure patients: design and rationale of the EXACT-HF study

Circ Heart Fail. 2013 Jul;6(4):862-8. doi: 10.1161/CIRCHEARTFAILURE.113.000394.
No abstract available

Keywords: allopurinol; clinical trial; heart failure; xanthine oxidase.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Allopurinol / therapeutic use
  • Disease Progression
  • Dose-Response Relationship, Drug
  • Endothelium, Vascular / physiopathology
  • Free Radical Scavengers / therapeutic use
  • Heart Failure / complications*
  • Humans
  • Hyperuricemia / complications*
  • Hyperuricemia / drug therapy*
  • Oxidative Stress / physiology
  • Patient Selection
  • Quality of Life
  • Randomized Controlled Trials as Topic*
  • Reactive Oxygen Species / metabolism
  • Research Design*
  • Xanthine Oxidase / antagonists & inhibitors*

Substances

  • Free Radical Scavengers
  • Reactive Oxygen Species
  • Allopurinol
  • Xanthine Oxidase