Mannose binding lectin and mannose binding lectin-associated serine protease-2 genes polymorphisms in human T-lymphotropic virus infection

J Med Virol. 2013 Oct;85(10):1829-35. doi: 10.1002/jmv.23656. Epub 2013 Jul 16.

Abstract

Variations in genes involved in the immune response pathways may influence the interaction between viruses (such as Human T-lymphotropic virus, HTLV-1) and the host. The mannose binding lectin (MBL) and its associated serine protease type 2 (MASP-2) promote the activation of the lectin pathway of the complement system. As the interaction of complement system with HTLV-1 is not well understood, the MBL2 promoter/exon 1 polymorphisms and a MASP2 missense polymorphism were examined in a Northeast Brazilian population, looking for a possible relationship between these variations and the susceptibility to HTLV-1 infection. The present study describes an association between a polymorphism in the MASP2 gene and susceptibility to HTLV-1 infection, and provides further evidence of an association between the MBL2 gene and HTLV-1 infection. These findings suggest an important role of the complement system activation, via the lectin pathway, in the susceptibility to HTLV-1 infection.

Keywords: HTLV; MASP2; MBL2; SNPs; innate immunity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brazil
  • Complement System Proteins / immunology
  • Exons
  • Female
  • Genetic Predisposition to Disease*
  • HTLV-I Infections / genetics*
  • HTLV-I Infections / immunology*
  • Humans
  • Male
  • Mannose-Binding Lectin / genetics*
  • Mannose-Binding Protein-Associated Serine Proteases / genetics*
  • Middle Aged
  • Mutation, Missense
  • Polymorphism, Genetic*
  • Promoter Regions, Genetic
  • Young Adult

Substances

  • MBL2 protein, human
  • Mannose-Binding Lectin
  • Complement System Proteins
  • MASP2 protein, human
  • Mannose-Binding Protein-Associated Serine Proteases