New steroids and sesquiterpene from Turraea pubescens

Fitoterapia. 2013 Oct:90:119-25. doi: 10.1016/j.fitote.2013.07.006. Epub 2013 Jul 13.

Abstract

Four new compounds, including three new steroids (1-3) and one new sesquiterpene (6), and two new natural products (4-5), as well as three known steroids (7-9) were isolated from the twigs of Turraea pubescens. Compounds 3-5 are C₂₂ steroids isolated from the Meliaceae family for the first time. Their structures were elucidated by extensive NMR and MS analyses. Compound 1 exhibited inhibitory activity against lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW264.7 cells with an IC₅₀ value of 11.5 μM.

Keywords: Anti-inflammatory; Meliaceae; Sesquiterpene; Steroids; Turraea pubescens.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / isolation & purification*
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use
  • Cell Line
  • Inflammation / chemically induced
  • Inflammation / drug therapy
  • Inflammation / metabolism
  • Inhibitory Concentration 50
  • Lipopolysaccharides
  • Meliaceae / chemistry*
  • Mice
  • Molecular Structure
  • Nitric Oxide / biosynthesis*
  • Phytosterols / chemistry
  • Phytosterols / isolation & purification*
  • Phytosterols / pharmacology
  • Phytosterols / therapeutic use
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plant Stems
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Sesquiterpenes / therapeutic use

Substances

  • Anti-Inflammatory Agents
  • Lipopolysaccharides
  • Phytosterols
  • Plant Extracts
  • Sesquiterpenes
  • turranin A
  • Nitric Oxide