Abstract
Four new compounds, including three new steroids (1-3) and one new sesquiterpene (6), and two new natural products (4-5), as well as three known steroids (7-9) were isolated from the twigs of Turraea pubescens. Compounds 3-5 are C₂₂ steroids isolated from the Meliaceae family for the first time. Their structures were elucidated by extensive NMR and MS analyses. Compound 1 exhibited inhibitory activity against lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW264.7 cells with an IC₅₀ value of 11.5 μM.
Keywords:
Anti-inflammatory; Meliaceae; Sesquiterpene; Steroids; Turraea pubescens.
© 2013.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology
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Anti-Inflammatory Agents / therapeutic use
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Cell Line
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Inflammation / chemically induced
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Inflammation / drug therapy
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Inflammation / metabolism
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Inhibitory Concentration 50
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Lipopolysaccharides
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Meliaceae / chemistry*
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Mice
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Molecular Structure
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Nitric Oxide / biosynthesis*
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Phytosterols / chemistry
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Phytosterols / isolation & purification*
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Phytosterols / pharmacology
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Phytosterols / therapeutic use
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
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Plant Stems
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Sesquiterpenes / therapeutic use
Substances
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Anti-Inflammatory Agents
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Lipopolysaccharides
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Phytosterols
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Plant Extracts
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Sesquiterpenes
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turranin A
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Nitric Oxide