Novel cholinesterase modulators and their ability to interact with DNA

Spectrochim Acta A Mol Biomol Spectrosc. 2013 Nov:115:364-9. doi: 10.1016/j.saa.2013.06.008. Epub 2013 Jun 17.

Abstract

In the present work, an interaction of four cholinesterase modulators (1-4) with calf thymus DNA was studied via spectroscopic techniques (UV-Vis, fluorescent spectroscopy and circular dichroism). From UV-Vis spectroscopic analysis, the binding constants for DNA-pyridinium oximes complexes were calculated (K=3.5×10(4) to 1.4×10(5)M(-1)). All these measurements indicated that the compounds behave as effective DNA-interacting agents. Electrophoretic techniques proved that ligand 2 inhibited topoisomerase I at a concentration 5μM.

Keywords: Cholinesterase modulators; DNA; Topoisomerase I.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bromides / chemistry
  • Bromides / metabolism*
  • Bromides / pharmacology*
  • Cholinesterases / metabolism*
  • Circular Dichroism
  • DNA / metabolism*
  • DNA Topoisomerases, Type I / metabolism
  • Electrophoresis, Agar Gel
  • Ethidium / metabolism
  • Plasmids / metabolism
  • Spectrometry, Fluorescence
  • Spectrophotometry, Ultraviolet

Substances

  • Bromides
  • DNA
  • calf thymus DNA
  • Cholinesterases
  • DNA Topoisomerases, Type I
  • Ethidium