First confirmation by genotyping of transplacental choriocarcinoma transmission

Am J Obstet Gynecol. 2013 Oct;209(4):e4-6. doi: 10.1016/j.ajog.2013.07.002. Epub 2013 Jul 11.

Abstract

A mother developed multimetastatic gestational choriocarcinoma 13 months after delivery, and her infant died aged 11 months from the same tumor. The transplacental choriocarcinoma transmission was confirmed by genotyping. Henceforth, we recommend a 2-year maternal human chorionic gonadotropin follow-up after neonatal choriocarcinoma and extensive imaging if the human chorionic gonadotropin rises.

Keywords: choriocarcinoma; chorionic gonadotropin; genotyping; gestational trophoblastic disease; neoplasm metastasis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor
  • Choriocarcinoma / blood
  • Choriocarcinoma / genetics
  • Choriocarcinoma / secondary*
  • Chorionic Gonadotropin / blood*
  • Female
  • Genotype
  • Humans
  • Infant
  • Liver Neoplasms / blood
  • Liver Neoplasms / genetics
  • Liver Neoplasms / secondary*
  • Male
  • Maternal-Fetal Exchange*
  • Neoplasm Metastasis
  • Pregnancy
  • Pregnancy Complications, Neoplastic / blood
  • Pregnancy Complications, Neoplastic / genetics
  • Pregnancy Complications, Neoplastic / pathology*
  • Uterine Neoplasms / blood
  • Uterine Neoplasms / genetics
  • Uterine Neoplasms / pathology*

Substances

  • Biomarkers, Tumor
  • Chorionic Gonadotropin