Paramagnetic solid lipid nanoparticles as a novel platform for the development of molecular MRI probes

Chemistry. 2013 Aug 19;19(34):11189-93. doi: 10.1002/chem.201301837. Epub 2013 Jul 10.

Abstract

Highly efficient magnetic resonance imaging (MRI) probes have been prepared by loading Gd(III) complexes on the surface of solid lipid nanoparticles (pSLNs). Applicability as molecular imaging probes is demonstrated by an in vitro model study with targeted pSLNs.

Keywords: contrast agents; lanthanides; lipidic nanoparticles; magnetic resonance imaging; relaxivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Coordination Complexes / chemistry
  • Gadolinium / chemistry
  • Humans
  • Lipids / chemistry*
  • Magnetic Resonance Imaging
  • Magnetics
  • Microscopy, Confocal
  • Molecular Probes / chemistry*
  • Nanoparticles / chemistry*

Substances

  • Coordination Complexes
  • Lipids
  • Molecular Probes
  • Gadolinium