Full-field optical coherence tomography using immersion Mirau interference microscope

Appl Opt. 2013 Jun 20;52(18):4400-3. doi: 10.1364/AO.52.004400.

Abstract

In this study, an immersion Mirau interference microscope was developed for full-field optical coherence tomography (FFOCT). Both the reference and measuring arms of the Mirau interferometer were filled with water to prevent the problems associated with imaging a sample in air with conventional FFOCT systems. The almost-common path interferometer makes the tomographic system less sensitive to environmental disturbances. En face OCT images at various depths were obtained with phase-shifting interferometry and Hariharan algorithm. This immersion interferometric method improves depth and quality in three-dimensional OCT imaging of scattering tissue.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Air
  • Algorithms
  • Image Processing, Computer-Assisted / instrumentation
  • Image Processing, Computer-Assisted / methods
  • Imaging, Three-Dimensional / instrumentation
  • Imaging, Three-Dimensional / methods
  • Interferometry / instrumentation*
  • Interferometry / methods
  • Microscopy / instrumentation*
  • Microscopy / methods
  • Onions / chemistry
  • Scattering, Radiation
  • Tomography, Optical Coherence / instrumentation*
  • Tomography, Optical Coherence / methods
  • Water / chemistry

Substances

  • Water