Abstract
There are a number of dynamic regulatory loops that maintain homeostasis of the immune and skeletal systems. In this review, we highlight a number of these regulatory interactions that contribute to maintaining homeostasis. In addition, we review data on a negative regulatory feedback loop between osteoclasts and CD8 T cells that contributes to homeostasis of both the skeletal and immune systems.
MeSH terms
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Bone and Bones / cytology
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Bone and Bones / immunology
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Bone and Bones / metabolism*
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CD8-Positive T-Lymphocytes / cytology
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CD8-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / metabolism*
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Cell Communication
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Feedback, Physiological
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Gene Expression Regulation
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Homeostasis / immunology*
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Humans
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Immune System / metabolism*
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Interferon-gamma / genetics
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Interferon-gamma / immunology
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Interleukin-10 / genetics
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Interleukin-10 / immunology
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Interleukin-6 / genetics
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Interleukin-6 / immunology
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Osteoclasts / cytology
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Osteoclasts / immunology
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Osteoclasts / metabolism*
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RANK Ligand / genetics
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RANK Ligand / immunology
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Signal Transduction
Substances
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IL10 protein, human
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IL6 protein, human
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Interleukin-6
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RANK Ligand
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TNFSF11 protein, human
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Interleukin-10
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Interferon-gamma