A Case of Multifocal Papillary Thyroid Carcinoma Consisting of One Encapsulated Follicular Variant with BRAF K601E Mutation and Three Conventional Types with BRAF V600E Mutation

Wook Youn Kim; Young Sin Ko; Tae Sook Hwang; Hye Seung Han; So Dug Lim; Wan Seop Kim; Seo Young Oh

doi:10.4132/KoreanJPathol.2013.47.3.293

A Case of Multifocal Papillary Thyroid Carcinoma Consisting of One Encapsulated Follicular Variant with BRAF K601E Mutation and Three Conventional Types with BRAF V600E Mutation

Korean J Pathol. 2013 Jun;47(3):293-8. doi: 10.4132/KoreanJPathol.2013.47.3.293. Epub 2013 Jun 25.

Authors

Wook Youn Kim¹, Young Sin Ko, Tae Sook Hwang, Hye Seung Han, So Dug Lim, Wan Seop Kim, Seo Young Oh

Affiliation

¹ Department of Pathology, Konkuk University School of Medicine, Seoul, Korea.

PMID: 23837025
PMCID: PMC3701828
DOI: 10.4132/KoreanJPathol.2013.47.3.293

Abstract

Multifocal papillary thyroid carcinoma (mPTC) comprises about 20-30% of PTC. In mPTC, individual tumor foci can be identical or frequently composed of different histological types including follicular, solid, tall-cell or conventional patterns. We report a case of mPTC consisting of one encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) and three conventional PTCs in a 44-year-old woman. This case genetically demonstrates unique features including the simultaneous presence of the BRAF V600E (T1799A) mutation and the BRAF K601E (A1801G) mutation in conventional PTC and FVPTC, respectively.

Keywords: BRAF K601E; BRAF V600E; Carcinoma, papillary; Thyroid gland.