Abstract
Each subunit of voltage-gated cation channels comprises a voltage-sensing domain and a pore region. In a paper recently published in Cell Research, Li et al. showed that the gating charge pathway of the voltage sensor of the KCNQ2 K+ channel can accommodate small opener molecules and offer a new target to treat hyperexcitability disorders.
MeSH terms
-
Animals
-
Anticonvulsants / metabolism*
-
Benzamides / pharmacology*
-
Epilepsy / metabolism*
-
KCNQ2 Potassium Channel / metabolism*
-
Male
-
Pyridines / pharmacology*
-
Shaker Superfamily of Potassium Channels / metabolism*
Substances
-
Anticonvulsants
-
Benzamides
-
KCNQ2 Potassium Channel
-
N-(6-chloropyridin-3-yl)-4-fluorobenzamide
-
Pyridines
-
Shaker Superfamily of Potassium Channels