Channel gating pore: a new therapeutic target

Cell Res. 2013 Sep;23(9):1067-8. doi: 10.1038/cr.2013.89. Epub 2013 Jul 9.

Abstract

Each subunit of voltage-gated cation channels comprises a voltage-sensing domain and a pore region. In a paper recently published in Cell Research, Li et al. showed that the gating charge pathway of the voltage sensor of the KCNQ2 K+ channel can accommodate small opener molecules and offer a new target to treat hyperexcitability disorders.

Publication types

  • Comment

MeSH terms

  • Animals
  • Anticonvulsants / metabolism*
  • Benzamides / pharmacology*
  • Epilepsy / metabolism*
  • KCNQ2 Potassium Channel / metabolism*
  • Male
  • Pyridines / pharmacology*
  • Shaker Superfamily of Potassium Channels / metabolism*

Substances

  • Anticonvulsants
  • Benzamides
  • KCNQ2 Potassium Channel
  • N-(6-chloropyridin-3-yl)-4-fluorobenzamide
  • Pyridines
  • Shaker Superfamily of Potassium Channels