Pathogenesis of exercise-induced bronchoconstriction

Abstract

This article presents the various potential mechanisms responsible for the development of exercise-induced bronchoconstriction (EIB). Although the etiology of EIB is multifactorial, and the physiologic processes involved may vary between individuals (especially between those with and without asthma), drying of the small airways with an associated inflammatory response seems prerequisite for EIB. Dysregulated repair processes following exercise-induced airway epithelial injury may also serve as basis for EIB development/progression.

Keywords: Airway inflammation; Epithelial injury; Hyperpnoea; Osmotic stress; Thermal stress.