Sweet nothings: sensing of sugar metabolites controls T cell function

Cell Metab. 2013 Jul 2;18(1):7-8. doi: 10.1016/j.cmet.2013.06.009.

Abstract

Signal transduction and metabolism cooperate to control cell fate, but mechanisms that link metabolic substrates to functional decisions are elusive. Now, Chang et al. (2013) in Cell provide a mechanism whereby available sugars dictate metabolic pathways in activated T cells and direct a nonmetabolic regulatory function of glyceraldehyde-3-phosphate dehydrogenase.

Publication types

  • Comment

MeSH terms

  • Animals
  • Glycolysis*
  • Lymphocyte Activation*
  • Oxidative Phosphorylation*
  • T-Lymphocytes / cytology*
  • T-Lymphocytes / metabolism*