Human visceral-fat-specific glucocorticoid tuning of adipogenesis

Cell Metab. 2013 Jul 2;18(1):3-5. doi: 10.1016/j.cmet.2013.06.008.

Abstract

Central obesity and long-term glucocorticoid exposure are both characterized by visceral fat enlargement and increased risk for metabolic diseases. In this issue of Cell Metabolism, Lindroos et al. identify LIM domain only 3 as a molecular partner for glucocorticoids required for adipocyte differentiation specifically in human visceral fat.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / physiology*
  • Adipogenesis / physiology*
  • Animals
  • Female
  • Humans
  • Intra-Abdominal Fat / physiology*
  • LIM Domain Proteins / physiology*
  • Male
  • Obesity / physiopathology*
  • Up-Regulation / physiology*

Substances

  • Adaptor Proteins, Signal Transducing
  • LIM Domain Proteins
  • LMO3 protein, human