[Long-term survival of metastatic clear cell adenocarcinoma of the female urethra by multidisciplinary treatment: a case report]

Nihon Hinyokika Gakkai Zasshi. 2013 May;104(3):549-53. doi: 10.5980/jpnjurol.104.549.
[Article in Japanese]

Abstract

We report a case of clear cell adenocarcinoma of the female urethra. A 57-year-old woman presented with complaint of gross hematuria. Abdominal ultrasonography, cystourethroscopy, computed tomography (CT) and magnetic resonance imaging (MRI) revealed the urethral tumor was invasive to bladder neck. Clinical stage was determined as cT3N1M0, then anterior pelvic exenteration and ileal conduit formation were performed. The pathological diagnosis was clear cell adenocarcinoma of urethra and the stage was pT3N1. The patient received TS-1 and cisplatin for postoperative recurrence, but she died from multiple lung metastasis 54 months after the operation. Clear cell adenocarcinoma of the female urethra is rare case in the Japanese literatures. Pathogenesis and management of this rare condition are discussed.

Publication types

  • Case Reports
  • English Abstract
  • Review

MeSH terms

  • Adenocarcinoma, Clear Cell / pathology
  • Adenocarcinoma, Clear Cell / secondary
  • Adenocarcinoma, Clear Cell / therapy*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cisplatin / administration & dosage
  • Combined Modality Therapy
  • Fatal Outcome
  • Female
  • Humans
  • Lung Neoplasms / secondary
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local / therapy
  • Neoplasm Staging
  • Silicates / administration & dosage
  • Time Factors
  • Titanium / administration & dosage
  • Treatment Outcome
  • Urethral Neoplasms / pathology
  • Urethral Neoplasms / therapy*
  • Urinary Bladder Neoplasms / pathology
  • Urologic Surgical Procedures

Substances

  • Silicates
  • titanium silicide
  • Titanium
  • Cisplatin