Abstract
We examined the effects of tigecycline on three types of exoproteins, α-type phenol-soluble modulins (PSMα1 to PSMα4), α-hemolysin, and protein A, in 13 methicillin-resistant Staphylococcus aureus isolates compared to those of clindamycin and linezolid. Paradoxical increases in PSMαs occurred in 77% of the isolates with tigecycline at 1/4 and 1/8 MICs and clindamycin at 1/8 MIC compared to only 23% of the isolates with linezolid at 1/8 MIC. Induction was specific to PSMα1 to PSMα4, as protein A and α-hemolysin production was decreased under the same conditions by all of the antibiotics used.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / pharmacology
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Anti-Bacterial Agents / pharmacology*
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Bacterial Toxins / agonists*
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Bacterial Toxins / biosynthesis
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Clindamycin / pharmacology
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Culture Media
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Humans
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Linezolid
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Methicillin-Resistant Staphylococcus aureus / growth & development
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Methicillin-Resistant Staphylococcus aureus / metabolism
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Methicillin-Resistant Staphylococcus aureus / pathogenicity
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Microbial Sensitivity Tests
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Minocycline / analogs & derivatives*
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Minocycline / pharmacology
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Oxazolidinones / pharmacology
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Protein Isoforms / agonists
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Protein Isoforms / biosynthesis
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Staphylococcal Infections / drug therapy
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Staphylococcal Infections / microbiology
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Tigecycline
Substances
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Acetamides
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Anti-Bacterial Agents
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Bacterial Toxins
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Culture Media
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Oxazolidinones
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Protein Isoforms
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staphylococcal delta toxin
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Clindamycin
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Tigecycline
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Minocycline
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Linezolid