Abstract
We report a case of Candida glabrata candidemia that developed resistance to micafungin within 8 days of initiation of therapy in a patient without previous echinocandin exposure or other known risk factors for clinical or microbiological failure. Pre- and postresistant isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed a phenylalanine deletion at codon 659 within FKS2.
MeSH terms
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Antifungal Agents / pharmacology*
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Candida glabrata / drug effects*
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Candida glabrata / enzymology
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Candida glabrata / genetics
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Candidemia / drug therapy*
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Candidemia / microbiology
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Drug Resistance, Fungal / drug effects
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Drug Resistance, Fungal / genetics*
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Echinocandins / pharmacology*
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Female
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Fungal Proteins / genetics*
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Fungal Proteins / metabolism
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Glucosyltransferases / genetics*
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Glucosyltransferases / metabolism
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Humans
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Microbial Sensitivity Tests
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Middle Aged
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Mutation
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Sequence Analysis, DNA
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Time Factors
Substances
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Antifungal Agents
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Echinocandins
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Fungal Proteins
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Glucosyltransferases