[The use of hydroxamic acids and sodium nitrate to enhance the antitumor effect of cyclophosphamide]

T N Bogatyrenko; Z V Kuropteva; T E Sashenkova; L M Baĭder; N P Konovalova

[The use of hydroxamic acids and sodium nitrate to enhance the antitumor effect of cyclophosphamide]

Vopr Onkol. 2013;59(1):94-8.

[Article in Russian]

Authors

T N Bogatyrenko, Z V Kuropteva, T E Sashenkova, L M Baĭder, N P Konovalova

PMID: 23814833

Abstract

It has been showed that the introduction of nitrocompounds (as nitic oxide donors) in to the compositions of cyclophosphamide and hydroxamic acids for curing animals having leukemia P-388 increased duration of life by 290%. Thereby 40% of animals have recovered. The therapeutic dose cyclophosphamide have been reduced by 6 times.

Publication types

English Abstract

MeSH terms

Animals
Antineoplastic Agents / pharmacology*
Cyclophosphamide / pharmacology*
Drug Synergism
Female
Hydroxamic Acids / pharmacology*
Leukemia P388 / drug therapy*
Male
Mice
Nitrates / pharmacology*
Survival Analysis
Treatment Outcome

Substances

Antineoplastic Agents
Hydroxamic Acids
Nitrates
sodium nitrate
Cyclophosphamide