A single histrelin implant is effective for 2 years for treatment of central precocious puberty

J Pediatr. 2013 Oct;163(4):1214-6. doi: 10.1016/j.jpeds.2013.05.033. Epub 2013 Jul 1.

Abstract

We investigated whether a "yearly" histrelin implant would provide pubertal suppression when left in place for 2 years. Equivalent suppression was observed when comparing 12 and 24 months in 33 children with central precocious puberty. A single implant for 2 years reduces cost and number of implant procedures.

Keywords: CPP; Central precocious puberty; GnRHa; Gonadotropin releasing hormone analog; HPG; Hypothalamic-pituitary-gonadal; LH; Luteinizing hormone; US; Ultrasensitive.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Drug Implants*
  • Female
  • Gonadotropin-Releasing Hormone / administration & dosage
  • Gonadotropin-Releasing Hormone / analogs & derivatives*
  • Gonadotropin-Releasing Hormone / therapeutic use
  • Humans
  • Hypothalamo-Hypophyseal System / drug effects
  • Luteinizing Hormone / blood
  • Male
  • Puberty, Precocious / drug therapy*
  • Sex Factors
  • Time Factors

Substances

  • Drug Implants
  • Gonadotropin-Releasing Hormone
  • Luteinizing Hormone
  • histrelin