We investigated whether a "yearly" histrelin implant would provide pubertal suppression when left in place for 2 years. Equivalent suppression was observed when comparing 12 and 24 months in 33 children with central precocious puberty. A single implant for 2 years reduces cost and number of implant procedures.
Keywords: CPP; Central precocious puberty; GnRHa; Gonadotropin releasing hormone analog; HPG; Hypothalamic-pituitary-gonadal; LH; Luteinizing hormone; US; Ultrasensitive.
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