Caesalpins A-H, bioactive cassane-type diterpenes from the seeds of Caesalpinia minax

Guoxu Ma; Jingquan Yuan; Haifeng Wu; Li Cao; Xiaopo Zhang; Lijia Xu; Hua Wei; Lizhen Wu; Qingxia Zheng; Liyong Li; Lijing Zhang; Junshan Yang; Xudong Xu

doi:10.1021/np300918q

Caesalpins A-H, bioactive cassane-type diterpenes from the seeds of Caesalpinia minax

J Nat Prod. 2013 Jun 28;76(6):1025-31. doi: 10.1021/np300918q. Epub 2013 Jun 12.

Authors

Guoxu Ma¹, Jingquan Yuan, Haifeng Wu, Li Cao, Xiaopo Zhang, Lijia Xu, Hua Wei, Lizhen Wu, Qingxia Zheng, Liyong Li, Lijing Zhang, Junshan Yang, Xudong Xu

Affiliation

¹ Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, People's Republic of China.

PMID: 23806110
DOI: 10.1021/np300918q

Abstract

Eight new cassane-type diterpenes, caesalpins A-H (1-8), were isolated from the ethyl acetate extract of Caesalpinia minax. Compound 1 displayed significant antiproliferative activity against HepG-2 (IC50 4.7 μM) and MCF-7 (IC50 2.1 μM) cells, and compounds 2 and 4 exhibited selective cytotoxic activities against MCF-7 (IC50 7.9 μM) and AGS (IC50 6.5 μM) cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Caesalpinia / chemistry*
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology*
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal / chemistry
Drugs, Chinese Herbal / isolation & purification*
Drugs, Chinese Herbal / pharmacology*
Female
Hep G2 Cells
Humans
Inhibitory Concentration 50
MCF-7 Cells
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Seeds / chemistry

Substances

Diterpenes
Drugs, Chinese Herbal