Microphyllandiolide, a new diterpene with an unprecedented skeleton from Salvia microphylla

Org Lett. 2013 Jul 5;15(13):3210-3. doi: 10.1021/ol401022c. Epub 2013 Jun 26.

Abstract

Microphyllandiolide (1), an unprecedented rearranged clerodane-type diterpene with a 9/3 bicyclic ring system, was isolated from the aerial parts of Salvia microphylla Kunth. Its structure was elucidated by analysis of its spectroscopic data and confirmed by single crystal X-ray diffraction analysis. A possible biogenesis for microphyllandiolide (1) is proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • Diterpenes, Clerodane / chemical synthesis*
  • Diterpenes, Clerodane / chemistry*
  • Diterpenes, Clerodane / isolation & purification
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Molecular Structure
  • Salvia / chemistry*
  • X-Ray Diffraction

Substances

  • Diterpenes, Clerodane
  • microphyllandiolide