Abstract
Two new acridone alkaloids, 3-methoxy-1,4,5-trihydroxy-10-methylacridone (1) and 2,3-dimethoxy-1,4,5-trihydroxy-10-methylacridone (2), were isolated from the ethanol extract of the branch of Atalantia buxifolia. Their structures were elucidated by spectroscopic methods including 1D and 2D NMR. Compounds 1 and 2 exhibited significant antibacterial activity against Staphylococcus aureus and weak inhibitory effect on acetylcholinesterase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase
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Acridines / chemistry
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Acridines / isolation & purification*
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Acridines / pharmacology*
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Acridones
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / isolation & purification*
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Cholinesterase Inhibitors / pharmacology*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
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Rutaceae / chemistry*
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Staphylococcus aureus / drug effects
Substances
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2,3-dimethoxy-1,4,5-trihydroxy-10-methylacridone
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3-methoxy-1,4,5-trihydroxy-10-methylacridone
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Acridines
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Acridones
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Alkaloids
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Anti-Bacterial Agents
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Cholinesterase Inhibitors
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Drugs, Chinese Herbal
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acridone
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Acetylcholinesterase