Serum selenium levels of the very low birth weight premature newborn infants with bronchopulmonary dysplasia

Abstract

Background: The selenium (Se) is an essential trace element that has a critical role in synthesis and activity of a number of selenoproteins with protective properties against free radical damage. This study was conducted to detect the serum Se concentration in very low birth weight (VLBW) preterm infants and its association with bronchopulmonary dysplasia (BPD).

Materials and methods: Cord blood Se concentration was determined in 54 neonates with gestation age 30 week or less. Another sample was obtained from these infants at day 28 of birth and serum Se levels were measured by atomic absorption spectrophotometer. All neonates were followed for oxygen dependency at 28 day after birth and 36 week postmenstrual age.

Results: The mean cord blood Se concentration in studied neonates was 64.78 ± 20.73 μgL(-1). Serum Se concentration was 60.33 ± 26.62 μgL(-1) at age 28-day. No significant correlation was observed for serum Se concentration at birth and at one month after birth (r = -0.04, p = 0.72). BPD was diagnosed in 25 neonates (46%). The mean serum Se concentration at one month was 57.16 ± 29.68 μgL(-1) in patients with BPD (25 cases) and 63.27 ± 23.6 μgL(-1) in 29 patients without BPD (p = 0.40).

Conclusion: In our study, serum Se concentration at 28 day of birth was lower than cord blood levels in preterm neonates, but we have not found significant difference among patients who had BPD or not with respect to serum Se concentrations at this age.

Keywords: Bronchopulmonary dysplasia; Cord blood; Preterm infants; Selenium.