Equine multinodular pulmonary fibrosis in three horses in Australia

Aust Vet J. 2013 Jul;91(7):274-80. doi: 10.1111/avj.12072.

Abstract

Background: Equine multinodular pulmonary fibrosis (EMPF) is a recently described form of interstitial pneumonia associated with the presence of equine herpesvirus type 5 (EHV-5). Since 2007, several case reports from America, Europe and the United Kingdom have further characterised the clinical presentation and laboratory findings of this disease.

Case reports: Three Thoroughbred broodmares were diagnosed with EMPF. Diagnosis was based on lung histopathology and positive identification of EHV-5 using PCR DNA amplification. There was multiple organ involvement in all three cases, including identification of EHV-5 in hepatic tissue in one case. Two of the three horses died. Treatment with acyclovir was unsuccessful in one horse and one horse survived without antiviral or corticosteroid treatment.

Conclusion: This case series is, to the authors' knowledge, the first report of EMPF in Australia and adds to the clinical description of the disease.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Australia
  • Biopsy / veterinary
  • DNA, Viral / chemistry
  • DNA, Viral / genetics
  • Fatal Outcome
  • Female
  • Gammaherpesvirinae / genetics
  • Gammaherpesvirinae / isolation & purification*
  • Herpesviridae Infections / pathology
  • Herpesviridae Infections / veterinary*
  • Herpesviridae Infections / virology
  • Histocytochemistry / veterinary
  • Horse Diseases / pathology
  • Horse Diseases / virology*
  • Horses
  • Polymerase Chain Reaction / veterinary
  • Pulmonary Fibrosis / pathology
  • Pulmonary Fibrosis / veterinary*
  • Pulmonary Fibrosis / virology

Substances

  • DNA, Viral