Macplocimine A, a new 18-membered macrolide isolated from the filamentous sulfur bacteria Thioploca sp

J Antibiot (Tokyo). 2013 Jul;66(7):443-6. doi: 10.1038/ja.2013.52. Epub 2013 Jun 19.

Abstract

Macplocimine A (1), a rare naturally occurring 18-membered macrolide, was isolated from the marine-derived filamentous sulfur bacteria Thioploca sp. The structure was determined by a combination of spectroscopic techniques, including HRESIMS, 1D and 2D NMR analyses. 1 features a thymine group, which is attached to an aromatic fused 18-membered macrolide ring structure derived from a polyketide synthase biosynthetic pathway.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification*
  • Macrolides / chemistry*
  • Macrolides / isolation & purification*
  • Molecular Structure
  • Spectrum Analysis
  • Thiotrichaceae / chemistry*
  • Thiotrichaceae / classification
  • Thiotrichaceae / genetics
  • Thiotrichaceae / isolation & purification

Substances

  • Anti-Bacterial Agents
  • Macrolides