Abstract
Macplocimine A (1), a rare naturally occurring 18-membered macrolide, was isolated from the marine-derived filamentous sulfur bacteria Thioploca sp. The structure was determined by a combination of spectroscopic techniques, including HRESIMS, 1D and 2D NMR analyses. 1 features a thymine group, which is attached to an aromatic fused 18-membered macrolide ring structure derived from a polyketide synthase biosynthetic pathway.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / isolation & purification*
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Macrolides / chemistry*
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Macrolides / isolation & purification*
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Molecular Structure
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Spectrum Analysis
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Thiotrichaceae / chemistry*
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Thiotrichaceae / classification
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Thiotrichaceae / genetics
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Thiotrichaceae / isolation & purification
Substances
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Anti-Bacterial Agents
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Macrolides