Aeruginosins from a Microcystis sp. bloom material collected in Varanasi, India

J Nat Prod. 2013 Jun 28;76(6):1187-90. doi: 10.1021/np4001152. Epub 2013 Jun 18.

Abstract

Two novel biologically active short peptides, aeruginosins IN608 and IN652, were isolated from the cyanobacterium Microcystis sp. strain BHU006, which was collected from Durgakund water reservoir in Varanasi, India. Aeruginosins IN608 and IN652 are linear modified peptides containing four building blocks, one of which is the arogenate-derived modified amino acid 2-carboxy-6-hydroxyoctahydroindole. Aeruginosin IN608 and aeruginosin IN652 inhibit the activity of the proteolytic enzyme trypsin with IC50's of 4.3 and 4.1 μM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • India
  • Inhibitory Concentration 50
  • Microcystis / chemistry*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Oligopeptides / chemistry
  • Oligopeptides / isolation & purification*
  • Oligopeptides / pharmacology
  • Trypsin Inhibitors / chemistry
  • Trypsin Inhibitors / isolation & purification*
  • Trypsin Inhibitors / pharmacology
  • Water Supply

Substances

  • Oligopeptides
  • Trypsin Inhibitors
  • aeruginosin IN608
  • aeruginosin IN652