Abstract
A strategy involving free radical copolymerization of a difunctional oligomer and a small-molecule crosslinker to give sub-10 nm nanogels is proposed. These nanogels can adapt to surrounding temperatures and regulate the release of a preloaded model anticancer drug 5-fluorouracil.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Cross-Linking Reagents / chemistry
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Drug Carriers / chemistry*
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Drug Carriers / pharmacology
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Fluorouracil / chemistry
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Fluorouracil / pharmacology
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Gels / chemistry
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Methacrylates / chemistry
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Mice
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Nanostructures / chemistry*
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Particle Size
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Polyethylene Glycols / chemistry
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Polymerization
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Temperature
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Vinyl Compounds / chemistry
Substances
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Antineoplastic Agents
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Cross-Linking Reagents
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Drug Carriers
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Gels
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Methacrylates
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Vinyl Compounds
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poly(ethylene glycol)-dimethacrylate
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Polyethylene Glycols
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divinyl benzene
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Fluorouracil