Lower mannose-binding lectin contributes to deleterious H1N1 2009 infection in children

APMIS. 2014 Feb;122(2):136-9. doi: 10.1111/apm.12111. Epub 2013 Jun 12.

Abstract

Mannose-binding lectin (MBL) has broad range of activity against viruses through the mechanisms of neutralization, opsonization, and complement activation. Prior studies have demonstrated that MBL inactivated the season's influenza virus. Due to the fact that children have no neutralizing antibody against H1N1 2009 virus, innate immunity may be crucial in the defense against influenza. Therefore, we studied whether MBL levels played a role in H1N1 2009 infection in children. In a prospective survey, we revealed that MBL levels in ICU influenza cases were significantly lower than in children with influenza from infection disease ward. MBL may be involved in innate immune responses to H1N1 2009 infection in children.

Keywords: Children; H1N1 2009; MBL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Female
  • Hospitalization
  • Humans
  • Immunity, Innate*
  • Influenza A Virus, H1N1 Subtype / immunology*
  • Influenza, Human / immunology*
  • Influenza, Human / pathology
  • Influenza, Human / virology
  • Intensive Care Units
  • Lung / pathology
  • Lung / virology
  • Male
  • Mannose-Binding Lectin / immunology*
  • Mannose-Binding Lectin / metabolism
  • Prospective Studies

Substances

  • Mannose-Binding Lectin