STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells

Biomed Pharmacother. 2013 Jul;67(6):527-32. doi: 10.1016/j.biopha.2013.04.006. Epub 2013 May 7.

Abstract

In this study, we aimed to evaluate the cytotoxic and apoptotic effects of zoledronic acid on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on zoledronic acid-induced apoptosis. The results showed that zoledronic acid decreased proliferation, and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT3, -5A and -5B genes were significantly reduced in zoledronic acid-treated K562 cells. These data indicated that STAT inhibition by zoledronic acid may be therapeutic in CML patients following the confirmation with clinical studies.

Keywords: Chronic myeloid leukemia; STATs; Zoledronic acid.

MeSH terms

  • Apoptosis / drug effects*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Diphosphonates / pharmacology*
  • Humans
  • Imidazoles / pharmacology*
  • K562 Cells
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
  • STAT Transcription Factors / genetics
  • STAT Transcription Factors / metabolism*
  • Signal Transduction / drug effects
  • Zoledronic Acid

Substances

  • Diphosphonates
  • Imidazoles
  • STAT Transcription Factors
  • Zoledronic Acid