A plastic clock

Neuron. 2013 May 22;78(4):580-2. doi: 10.1016/j.neuron.2013.05.008.

Abstract

Although circadian clocks normally run with a 24 hr period, Brancaccio et al. (2013) report in this issue of Neuron that transiently activating G protein signaling can lengthen period even after the stimulus is removed, revealing an unexpected plasticity in the central brain clock.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Calcium Signaling / physiology*
  • Circadian Clocks / physiology*
  • Cyclic AMP Response Element-Binding Protein / metabolism*
  • GTP-Binding Protein alpha Subunits / metabolism*
  • Suprachiasmatic Nucleus / metabolism*
  • Vasoactive Intestinal Peptide / physiology*

Substances

  • Cyclic AMP Response Element-Binding Protein
  • GTP-Binding Protein alpha Subunits
  • Vasoactive Intestinal Peptide