Harnessing the considerable capacity of brown adipose tissue (BAT) to consume energy was first proposed as a potential target to control obesity nearly 40years ago. The plausibility of this approach was, however, questioned due to the prevailing view that BAT was either not present or not functional in adult humans. Recent definitive identification of functional BAT in adult humans as well as a number of important advances in the understanding of BAT biology has reignited interest in BAT as an anti-obesity target. Proof-of-concept evidence demonstrating drug-induced BAT activation provides an important foundation for development of targeted pharmacological approaches with clinical application. This review considers evidence from both human and relevant animal studies to determine whether harnessing BAT for the treatment of obesity via pharmacological intervention is a realistic goal.
Keywords: Adaptive thermogenesis; BAT; Beige adipose; Brite; Brown adipose; FDG; Obesity; PET–CT; UCP-1; WAT; brown adipose tissue; cBAT; classical BAT; fluorodeoxyglucose; positron emission tomography–computerized tomography; uncoupling protein-1; white adipose tissue.
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