Ozone and SIRT3: an unexplored paradigm

Exp Dermatol. 2013 Jun;22(6):396. doi: 10.1111/exd.12143.

Abstract

Exposure to environmentally relevant doses of ozone induces oxidative stress and is associated with adverse effects at tissue level. Delineating the role of sirtuin3, involved in cellular energy homoeostasis, in the response of skin to ozone can be a step towards developing prevention strategies against cutaneous pathologies.

Publication types

  • Editorial

MeSH terms

  • DNA Damage
  • Environmental Exposure
  • Gene Expression Regulation*
  • Homeostasis
  • Humans
  • Keratinocytes / drug effects
  • Oxidative Stress*
  • Ozone*
  • Sirtuin 3 / metabolism*
  • Skin / pathology*
  • Skin Diseases / etiology
  • Skin Diseases / pathology
  • Ultraviolet Rays

Substances

  • Ozone
  • SIRT3 protein, human
  • Sirtuin 3