Abstract
Two new compounds with five known compounds have been isolated from EtOH extract of the seeds of Nigella glandulifera. On the basis of their spectroscopic and chemical evidence, the new compounds were elucidated as methoxynigeglanine (1) and 6-methoxythymol-3-O-β-D-glucopyranoside (4). Compounds 1-4 showed moderate antitubercular activity against Mycobacterium tuberculosis strain H37Rv with minimal inhibitory concentration (MIC) values of 32-250 µg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / chemistry*
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Antitubercular Agents / isolation & purification
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Antitubercular Agents / pharmacology*
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Glucosides / chemistry
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Glucosides / isolation & purification
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Glucosides / pharmacology
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Humans
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects*
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Nigella / chemistry*
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Plant Extracts / chemistry*
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Seeds / chemistry
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Tuberculosis / drug therapy
Substances
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Antitubercular Agents
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Glucosides
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Plant Extracts