The AMPA receptor modulator S18986 in the prelimbic cortex enhances acquisition and retention of an odor-reward association

Neurosci Lett. 2013 Aug 26:548:105-9. doi: 10.1016/j.neulet.2013.05.032. Epub 2013 May 23.

Abstract

Systemic administration of S18986, a positive allosteric modulator of AMPA receptors, improves cognition. The present study further characterizes the drug's memory-enhancing properties and is the first to investigate its intracerebral effects on learning and memory. The results showed that rats receiving a single dose of S18986 (3 μg/site) into the prelimbic cortex, prior to olfactory discrimination acquisition, exhibited significantly shorter latencies and fewer errors to make the correct response, both in the acquisition and two drug-free retention tests. Such findings corroborate the involvement of glutamate receptors in odor-reward learning and confirm the role of the AMPAkine S18986 as a cognitive enhancer.

Keywords: AMPA receptors; Cognitive enhancer; Glutamate; Memory facilitation; Olfactory discrimination; Prefrontal cortex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Association Learning / drug effects
  • Association Learning / physiology*
  • Benzothiadiazines / pharmacology*
  • Male
  • Mental Recall / drug effects*
  • Mental Recall / physiology
  • Nootropic Agents / pharmacology
  • Odorants
  • Prefrontal Cortex / drug effects
  • Prefrontal Cortex / physiology*
  • Rats
  • Rats, Wistar
  • Receptors, AMPA / agonists*
  • Receptors, AMPA / metabolism
  • Retention, Psychology / drug effects
  • Retention, Psychology / physiology*
  • Reward*
  • Smell / drug effects
  • Smell / physiology

Substances

  • Benzothiadiazines
  • Nootropic Agents
  • Receptors, AMPA
  • S18986-1