Sleep and the functional connectome

Neuroimage. 2013 Oct 15:80:387-96. doi: 10.1016/j.neuroimage.2013.05.067. Epub 2013 May 24.

Abstract

Sleep and the functional connectome are research areas with considerable overlap. Neuroimaging studies of sleep based on EEG-PET and EEG-fMRI are revealing the brain networks that support sleep, as well as networks that may support the roles and processes attributed to sleep. For example, phenomena such as arousal and consciousness are substantially modulated during sleep, and one would expect this modulation to be reflected in altered network activity. In addition, recent work suggests that sleep also has a number of adaptive functions that support waking activity. Thus the study of sleep may elucidate the circuits and processes that support waking function and complement information obtained from fMRI during waking conditions. In this review, we will discuss examples of this for memory, arousal, and consciousness after providing a brief background on sleep and on studying it with fMRI.

Keywords: Arousal; Connectivity; Consciousness; Memory; Sleep.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Arousal / physiology*
  • Brain / physiology*
  • Connectome / methods*
  • Consciousness / physiology
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Models, Anatomic
  • Models, Neurological*
  • Nerve Net / physiology*
  • Sleep / physiology*