Abstract
Six new phenolic diglycosides, named gymnetinosides A-F (1-6), were isolated from the ethanolic extract of Gymnema tingens, together with three known diglycosides, sequinoside K (7), khaephuoside B (8), and albibrissinoside A (9). The structures of the new compounds were determined by spectroscopic techniques including 1D-, 2D NMR, mass spectroscopy, and circular dichroism. Compounds 1, 5, and 6 showed hepatoprotective activities against D-galactosamine-induced HL-7702 cell damage.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line / drug effects
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Circular Dichroism
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Drug Evaluation, Preclinical / methods
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Galactosamine / toxicity
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Glycosides / chemistry
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Glycosides / pharmacology
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Gymnema / chemistry*
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Phenols / chemistry
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Plant Extracts / analysis
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Protective Agents / chemistry*
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Protective Agents / pharmacology*
Substances
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Glycosides
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Phenols
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Plant Extracts
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Protective Agents
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Galactosamine