Concise solid-phase synthesis of inverse poly(amidoamine) dendrons using AB2 building blocks

Chem Commun (Camb). 2013 Jun 28;49(51):5784-6. doi: 10.1039/c3cc40661j.

Abstract

A concise solid-phase synthesis of inverse poly(amidoamine) dendrons was developed. Upon introduction of AB2-type monomers, each dendron generation was constructed via one reaction. G2 to G5 dendrons were constructed in a peptide synthesizer in 93%, 89%, 82%, and 78% yields, respectively, within 5 days.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Amines / chemistry
  • Automation
  • Carboxylic Acids / chemistry
  • Dendrimers / chemical synthesis*
  • Dendrimers / chemistry
  • Polyamines / chemistry*
  • Solid-Phase Synthesis Techniques

Substances

  • Amines
  • Carboxylic Acids
  • Dendrimers
  • Poly(amidoamine)
  • Polyamines